About 7pm on Friday, March 22, emergency services were called to the Hume Highway, Marulan, some 500 metres south of the Marulan South Road, following reports of truck and car crash.

NSW Ambulance Service attended, treating the driver of a sedan - a 77-year-old male driver - who suffered internal injuries. He was transported to Queanbeyan hospital.

The passenger - a 64-year-old female- was trapped before being released and sustained a serious head injury. She was airlifted to Canberra Hospital.

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The driver of the truck - a 37-year-old male - was not physically injured. He was transported to Goulburn Base Hospital for mandatory testing.

The crash occurred in the southbound lane.

Officers attached to the crash investigation unit attended the scene and commenced an investigation.